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Blog Archives

Molecular, proteomic and immunological parameters of allergens provide inclusion criteria for new candidates within established grass and tree homologous groups

Written on July 15, 2015 at 11:01 pm, by

Background: Our knowledge of allergen structure and function continues to rise and new scientific data on the homology and cross-reactivity of allergen sources should be considered to extend the work of Lorenz et al., 2009 (Int Arch Allergy Immunol. 148(1):1–1, 2009) and the concept of homologous groups. In addition to this, sophisticated techniques such as  Continue Reading »

Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization

Written on July 14, 2015 at 10:50 pm, by

The prevalence of allergic airway diseases such as asthma and rhinitis has increased dramatically to epidemic proportions worldwide. Besides air pollution from industry derived emissions and motor vehicles, the rising trend can only be explained by gross changes in the environments where we live. The world economy has been transformed over the last 25 years with  Continue Reading »

Oral immunotherapy and anti-IgE antibody treatment for food allergy

Written on July 6, 2015 at 9:19 pm, by

Food allergy is a major public health problem affecting nearly 10 % of children in most industrialized countries. Unfortunately, there are no effective therapies for food allergy, relegating patients to simply avoid the offending foods and treat reactions that occur on accidental exposure. Recently however, studies suggest that food immunotherapy may provide a promising new  Continue Reading »

The microbiome of the human lower airways: a next generation sequencing perspective

Written on June 18, 2015 at 5:35 pm, by

For a long time, the human lower airways were considered a sterile environment where the presence of microorganisms, typically revealed by culturing, was interpreted as an abnormal health state. More recently, high-throughput sequencing-based studies have led to a shift in this perception towards the notion that even in healthy conditions the lower airways show either  Continue Reading »

Genetic, familial and environmental correlates of asthma among early adolescents in Sri Lanka: a case control study

Written on June 17, 2015 at 5:18 pm, by

Background: Despite advances in management, the mortality and morbidity due to asthma are increasing globally. Identification of specific correlates in the local context is useful in disease management. The objective of this study was to estimate the prevalence and to describe selected correlates of asthma among12-14 year old school children in a district in Sri  Continue Reading »

Catching allergy by a simple questionnaire

Written on June 11, 2015 at 4:01 pm, by

Background: Identifying allergic rhinitis requires allergy testing, but the first-line referral for rhinitis are usually primary care (PCP), who are not familiar with such tests. The availability of easy and simple tests to be used by PCP to suggest allergy should be very useful. Methods: The Respiratory Allergy Prediction (RAP) test, based on 9 questions  Continue Reading »

Chronic urticaria merits serum vitamin D evaluation and supplementation; a randomized case control study

Written on June 10, 2015 at 3:52 pm, by

Background: Several studies suggest that Vitamin D (Vit-D3) supplementation reduces Chronic Urticaria (CU) symptoms.ObjectivesEvaluation of serum 25-hydroxyvitamin-D (25 (OH)2D) level and assessment of therapeutic effect of VitD3in CU patients. Methods: 192 subjects were stratified according to the baseline 25(OH)2D levels and subsequently randomized into three subgroups to receive Vit-D3 alone (VD) or antihistamine and systemic corticosteroid  Continue Reading »

Budesonide inhalation suspension versus methylprednisolone for treatment of moderate bronchial asthma attacks

Written on May 29, 2015 at 1:46 pm, by

Background: Owing to their side effects, administration of steroids for bronchial asthma attacks should be minimized. We investigated whether budesonide inhalation suspension (BIS) could replace intravenous steroid administration for the treatment of moderate bronchial asthma attacks.Subjects and MethodsThe subjects were children aged 5 years and younger hospitalized for moderate bronchial asthma attacks. Patients were randomly assigned  Continue Reading »

Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens

Written on May 29, 2015 at 1:46 pm, by

Substantial progress in understanding mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumors, organ transplantation and chronic infections has led to a variety of targeted therapeutic approaches. Allergen-specific immunotherapy (AIT) has been used for 100 years as a desensitizing therapy for allergic diseases and represents the potentially curative and specific way of treatment. The mechanisms  Continue Reading »

How an online survey on the treatment of allergic rhinitis and its impact on asthma (ARIA) detected specialty-specific knowledge-gaps

Written on May 29, 2015 at 1:46 pm, by

Background: To enhance the dissemination of the ARIA document (Allergic rhinitis (AR) and its impact on asthma) in Mexico, a Working Group composed of 35 specialists of 8 professional medical societies developed a transculturized ARIA México 2014 guideline. The ARIA guidelines use the GRADE system, which builds recommendations and suggestions around clinical questions (CQ). Methods:  Continue Reading »

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